Name: Sermorelin GHRH(1-29) Research Peptide
Brand: Koi Aminos
SKU: SERMORELIN
Availability: InStock

Question 1

What is Sermorelin?

Accepted Answer

Sermorelin (GRF(1-29), CAS 86168-78-7) is a synthetic 29-amino-acid C-terminal amide analog corresponding to the N-terminal 1-29 residues of growth-hormone-releasing hormone - the minimal GHRH fragment that retains full GH-releasing activity at GHRH-R. MW 3357.93 g/mol, formula C149H246N44O42S. It signals through Gs/cAMP, stimulating pulsatile GH release from pituitary somatotrophs. For in vitro laboratory research use only.

Question 2

Why is Sermorelin called the minimal GHRH fragment?

Accepted Answer

Native GHRH is 44 amino acids. Research has established that the first 29 N-terminal residues (GHRH 1-29) are sufficient to retain full GH-releasing activity at GHRH-R - the remaining 15 C-terminal residues are not required for receptor binding or signaling. Sermorelin is exactly these 29 residues, synthesized as a C-terminal amide. This makes it the shortest functional GHRH analog and the reference point for all structure-activity work studying which residues are required for GHRH-R activation.

Question 3

How does Sermorelin stimulate GH release?

Accepted Answer

Sermorelin binds GHRH-R (a Gs-coupled GPCR) on pituitary somatotroph cells, activating adenylyl cyclase and elevating cAMP. cAMP activates PKA, which phosphorylates CREB and triggers GH gene transcription and GH vesicle exocytosis. Because Sermorelin acts upstream of the pituitary, the pituitary's own feedback systems - including somatostatin negative feedback - remain intact, preserving the physiological pulsatile pattern of GH secretion. This is the mechanistic difference vs. direct GH administration.

Question 4

How does Sermorelin differ from Tesamorelin?

Accepted Answer

Sermorelin (GHRH 1-29, unprotected, MW 3357.93 g/mol) is subject to rapid dipeptidyl-peptidase cleavage at the N-terminus. Tesamorelin (GHRH 1-44 with N-terminal trans-3-hexenoyl modification, MW 5135.90 g/mol) is DPP-resistant. Both bind GHRH-R and stimulate pulsatile GH release through Gs/cAMP. Order both to run the definitive DPP stability comparison across the GHRH class - Sermorelin as the unprotected baseline, Tesamorelin as the protected long-acting analog.

Question 5

What is the CAS number and molecular weight of Sermorelin?

Accepted Answer

CAS number: 86168-78-7. MW: 3357.93 g/mol. Molecular formula: C149H246N44O42S. Also catalogued as GRF(1-29), GRF 1-29, Growth Hormone Releasing Factor 1-29 amide, and GHRH(1-29)NH2. The C-terminal amide distinguishes it from GHRH(1-29) free acid forms.

Question 6

Is Sermorelin FDA approved?

Accepted Answer

Sermorelin acetate was previously FDA-approved (Geref) for GH deficiency in children but was withdrawn from the US market in 2008. Research-grade Sermorelin sold here is for in vitro laboratory use only and is not approved by the FDA for therapeutic, diagnostic, or clinical application. Not for human or animal administration.

Question 7

What research applications is Sermorelin used for?

Accepted Answer

Sermorelin is used for: GHRH-R binding and cAMP-accumulation assays as the minimal-fragment GHRH reference; pituitary somatotroph GH-release studies in cell culture and rodent models; GHRH/GHRP secretagogue synergy experiments with GHS-R1a agonists such as Ipamorelin for additive pulsatile GH modeling; structure-activity studies of GHRH fragments and analogs examining minimal receptor activation requirements; N-terminal DPP cleavage kinetics - Sermorelin serves as the reference substrate for measuring DPP enzymatic activity rates; and comparative stability studies vs. tesamorelin (protected) and native GHRH(1-44).

Question 8

What documentation is available with Sermorelin?

Accepted Answer

A batch-specific Certificate of Analysis is publicly viewable. Use the lot number on your vial to access documentation covering HPLC purity (≥99%), LC-MS identity confirmation, net content, heavy metals by ICP-MS, sterility, and endotoxin.

Question 9

How should Sermorelin be stored?

Accepted Answer

Store the sealed lyophilized vial at −20°C, protected from light and humidity. Short-term refrigeration at 2–8°C is acceptable for immediate use within a few weeks. Reconstitute in sterile or bacteriostatic water at neutral pH. After reconstitution, store at 2–8°C and avoid repeated freeze-thaw cycles. Sermorelin's N-terminus is unprotected - minimize exposure to proteolytic conditions in assay buffers.

Question 10

What sizes are available for Sermorelin?

Accepted Answer

Sermorelin is available in 5mg ($59.95) and 10mg ($99.95) vials, both lyophilized powder. The two-size format supports both pilot GHRH-R binding assays (5mg) and full secretagogue synergy protocols with Ipamorelin or extended dose-response studies (10mg).

Sermorelin GHRH(1-29) Research Peptide

Key Takeaways

Key Scientific Specifications

Research-Referenced Attributes

Related Compounds

GLP-3 RT

GLP-3 R