Buy MOTS-c Research Peptide (AMPK MDP) | Koi Aminos
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MOTS-c research peptide
Lyophilized powder

MOTS-c Mitochondrial-Derived Peptide Research Compound

Mitochondrial Peptide · AMPK · Retrograde Signal

MOTS-c is the only research peptide encoded in mitochondrial DNA - a 16-amino-acid retrograde signal that translocates to the nucleus under metabolic stress to activate AMPK and regulate skeletal muscle glucose uptake.

Size: 10mg

$54.95/ 10mg≥99% HPLC
Buy Now on Koi Peptides - $54.95

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For Research Use Only. Not for human or animal use. Not intended to diagnose, treat, cure, or prevent any disease. Sold exclusively for laboratory and analytical research purposes.

CAS Number

1627580-64-6

Molecular Weight

1817.10 g/mol

Every other research peptide in this catalog is synthetic by design. MOTS-c is different - it is a signal your own mitochondria already produce. The research challenge is isolating it for in vitro work, which requires a synthetic version that matches the endogenous sequence exactly.

MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA gene of mitochondrial DNA. It is one of the only known retrograde signals that translocates from mitochondria to the nucleus under metabolic stress, where it activates AMPK, improves skeletal muscle glucose uptake, and modulates mitochondrial-nuclear communication. Multiple published cohort studies show circulating MOTS-c declines with age - establishing it as both a research tool and a biomarker reference in aging biology.

We supply MOTS-c at ≥99% HPLC purity in 10mg and 40mg vials. CAS 1627580-64-6, MW 1817.10 g/mol. Note: two methionine residues in the sequence are oxidation-sensitive - see storage guidance. For in vitro laboratory research use only.

Key Takeaways

→Mitochondrially encoded: one of the only peptides derived from mitochondrial DNA - not nuclear - making it a unique retrograde signaling reference
→Activates AMPK in skeletal muscle without receptor agonism - the same metabolic pathway targeted by metformin and exercise
→Circulating MOTS-c declines with age in multiple published cohorts - a biomarker reference for aging and metabolic decline research
→Two methionine residues are oxidation-sensitive - store lyophilized at -20°C and minimize reconstituted dwell time at room temperature
→10mg and 40mg vials - scale from pilot AMPK activation assays to extended glucose-uptake dose-response studies

Key Scientific Specifications

16-amino-acid mitochondrial-derived peptide (MDP) encoded in mitochondrial 12S rRNA gene
CAS 1627580-64-6 · MW 1817.10 g/mol · PubChem CID 146675088
≥99% purity by HPLC; identity confirmed by LC-MS; endotoxin and sterility tested
AMPK pathway activation studied in skeletal muscle cell and glucose-restriction models
Two Met residues in sequence - oxidation-sensitive; aliquot post-reconstitution and minimize freeze-thaw
Lot-specific COA: HPLC, LC-MS, weight, sterility, endotoxin (LPS), TFA content

Research-Referenced Attributes

Based on published preclinical and clinical literature; not therapeutic claims. For laboratory research use only.

AMPK pathway activation in skeletal muscle models without receptor agonism - MOTS-c as the endogenous mitochondrial AMPK activator reference
Glucose uptake studies in myocyte and adipocyte cell lines: comparing MOTS-c-stimulated vs. baseline glucose transport
Mitochondrial-nuclear retrograde signaling: mechanism by which mitochondrial-derived signals regulate nuclear gene expression under metabolic stress
Aging biology research: circulating MOTS-c plasma kinetics decline across lifespan in multiple human cohorts - biomarker reference for metabolic aging studies
Exercise physiology models: MOTS-c response to simulated exercise-induced metabolic stress in skeletal muscle cell models
Insulin sensitivity research: MOTS-c-mediated glucose uptake in insulin-resistant cell models and implications for metabolic dysfunction research

Also in This Research Area

Researchers working with MOTS-c frequently also order AOD-9604 hGH fragment for complementary metabolic pathway research, and GLP-3 RT triple-receptor agonist for incretin and mitochondrial signaling cross-pathway models. Both are available as lyophilized research-grade peptides on the Koi Aminos research peptide marketplace.

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GLP-3 R

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