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Retatrutide · Triple Agonist · GLP-1R / GIPR / GCGR
Single and dual GLP-1 agonists leave GCGR activation on the table. GLP-3 RT (Retatrutide) hits all three - GLP-1R, GIPR, and GCGR - the only way to model true triple-receptor crosstalk.
Lipidated Triple Agonist · GLP-1R / GIPR / GCGR
GLP-3R is the lipidated variant - a 39-amino-acid GLP-1R/GIPR/GCGR triagonist with a fatty acid conjugate that extends half-life and alters receptor-binding kinetics vs. unlipidated analogs.
Tirzepatide Class · Dual GIP/GLP-1 Agonist
GLP-2 TZ is the dual-agonist bridge in the GLP-1 class - it hits GIP and GLP-1 receptors simultaneously, positioning between semaglutide (GLP-1R only) and GLP-3 RT (GLP-1R + GIPR + GCGR).
hGH Fragment 176–191
AOD-9604 isolates the lipolytic region of hGH - the 16-amino-acid C-terminal fragment (176–191) that activates β3-adrenergic signaling without touching the GH receptor or IGF-1.
GHRH(1-44) Analog · DPP-Resistant · Growth-Hormone Axis
Tesamorelin is GHRH(1-44) with a critical upgrade - an N-terminal trans-3-hexenoyl group that blocks dipeptidyl-peptidase cleavage and extends enzymatic half-life far beyond native GHRH or sermorelin.
GHRH(1-29) Amide · Minimal GHRH Fragment · GH Secretagogue
Sermorelin (GRF 1-29) is the minimal GHRH fragment - 29 amino acids that retain full GH-releasing activity and serve as the DPP-stability reference for every longer GHRH analog.
Mitochondrial Peptide · AMPK · Retrograde Signal
MOTS-c is the only research peptide encoded in mitochondrial DNA - a 16-amino-acid retrograde signal that translocates to the nucleus under metabolic stress to activate AMPK and regulate skeletal muscle glucose uptake.